Sildenafil 100mg

Sildenafil Citrate 100mg. Aurogra. Generic Sildenafil citrate

Sildenafil citrate is the active constituent present in the most popular medication – Sildenafil citrate used for erectile dysfunction. This constituent in the medication is helpful for patients to achieve proper erection for sexual intercourse in presence sexual stimulation. Sildenafil citrate will not work in the absence of sexual arousal. SIldenafil citrate is the active ingredient of Aurogra, Viprogra and other generic Sildenafil citrate drugs.

Sildenafil Citrate (aurogra) Action Mechanism

Upon sexual arousal, nitrogen oxide (NO) is released in the penis in the cavernous body. The released nitrogen oxide helps in the activation of an enzyme called guanylate cyclase which in turn causes the increase of another enzyme called cyclic GMP or cGMP.

The elevation of cGMP levels will help in their interaction with proteins present in the smooth muscles of the penis in the cavernous body. This interaction will lead to relaxation of the smooth muscles in the penis thus enabling more blood to enter the penis resulting in erection.

Sildenafil citrate works by being an inhibitor of another enzyme called PDE5 or phoshodiesterase type-5. The PDE5 is an enzyme that is responsible for reversing the erection process by causing the breakdown of cGMP. By inhibiting the actions of PDE5, Sildenafil citrate will enable the person to retain the erection for a longer duration of time and facilitate sexual intercourse.

Sildenafil Citrate (Aurogra) Indications

Sildenafil citrate is indicated for use in men over the age of 18 years. It is used in the management of all forms of erectile dysfunction, namely, psychogenic, organic and mixed types. It can be used safely even in persons suffering from diabetes or spinal cord trauma. Obese persons suffering from erectile dysfunction also can safely use the medication without severe side effects.

Sildenafil Citrate Intake Instructions

Sildenafil citrate is available as a tablet to be taken through the oral route. The usual advised dose is 50mg in the period of a day. This needs to be taken about an hour prior to sexual activity for it to establish its actions. If the average dose is not showing therapeutic effects then the dose could be increased to 100mg in a day. However, in some individuals the dose might have to be adjusted to just 25mg in a day.

The maximum permissible safe dose is 100 mg in the period of a day. Sildenafil citrate is not recommended for use by women and by adolescents below the age of 18 years.

In Case of Overdose of Sildenafil Citrate (generic Sildenafil citrate)

It is best not to take the medication in a dose above what has been advised. If the dose exceeds the daily recommended dose, there is the high likelihood of increased adverse effects. In case of overdose, the usual adverse effects observed will include headache, dyspepsia, hot flashes, vision disturbances, fainting and reduction in the blood pressure. Usually the therapeutic intervention for overdose will include symptomatic management of adverse effects and stabilization.

Contraindications for Sildenafil Citrate 100mg (generic Sildenafil citrate)

Sildenafil citrate is contraindicated for use in some people. Some of the conditions in which the use of sildenafil is not advisable include:

• The medication is not recommended for use in women. The safety has not been thoroughly studied in women and the drug is definitely not indicated for use in pregnancy and women who breastfeed.
• Sildenafil citrate is not indicated for use in children and adolescents up to the age of 18 years.
• If the person is using nitrates or donors of nitric oxide then the medication is not advisable for use due to the serious risk of developing life threatening complications.

Generic Sildenafil citrate Adverse Effects

Like any other medication, the use of Sildenafil citrate can lead to some undesirable side effects. However, the extent of these adverse effects is only mild to moderate requiring no therapeutic intervention or cessation of medication. Some of the commonly observed adverse effects from the medication include headache, nasal congestion, dyspepsia, dizziness, vision disturbances and flushing.

If the medication is taken in a higher dose than advised, the risk of occurrence of side effects also increases. The use of a single dose of the medication in the strength of 100mg did not cause significant changes to the motility of sperms or to its morphology.

Sildenafil Citrate Special Precautions

A thorough investigation and assessment of the physical condition of the person should be done before arriving at diagnosis and management of erectile dysfunction. If the person is suffering from cardiovascular diseases, sexual activity can pose a risk in such individuals. So, prior to advising the intake of Sildenafil citrate it is essential to assess the cardiovascular system to avoid potential risks and complications.

If the person suffers from any form of anatomical penile deformation such as Peyronie’s disease, cavernous fibrosis or angulation, it is essential to use Sildenafil citrate with caution. The drug should be used with caution in persons suffering from priapism or any disorder that carries the risk of priapism like leukemia, multiple myeloma and sickle-cell anemia.

Sildenafil citrate safety in people with retinitis pigmentosa has not been thoroughly studied. Hence, people with this condition should use utmost caution in using the medication.

Sildenafil Citrate (Aurogra) Drug Interactions

The metabolism of Sildenafil citrate may be affected in the presence of cytochrome P450, isoforms 2C9 and inhibitors 3A4. Isoenzymes of P450 also might lead to reduced metabolism of the medication. The concomitant use of medication like cimetidine, ketoconazole and erythromycin also affects the metabolism of sildenafil and concomitant use is not advisable.

The bioavailability of active constituents of the medication is not altered when antacids are taken concomitantly. The effects of Sildenafil citrate is not altered in the presence of ACE inhibitors, beta-blockers, calcium antagonists, diuretics, rifampicin, barbiturates, warfarin, tricyclic antidepressants, and tolbutamide.

When used with aspirin, there is no alteration to the bleeding time. There is no significant change to the antihypertensive changes alcohol induces when Sildenafil citrate is used in combination.

Amlodipine can cause adverse reactions when taken concomitantly with the medication. Sildenafil citrate is also known to reduce blood pressure when it is taken in combination with nitrates and donors of nitric oxide and should be therefore avoided.

The effects of a combined use of Sildenafil citrate with other medications available for erectile dysfunction have not been thoroughly studied. Hence, the drugs should not be used concomitantly.